5 Amino 1 MQ – 5MG

Why Buy 5-Amino-1MQ?

Researchers buy 5-Amino-1MQ because it blocks an enzyme called NNMT and is a leading probe in fat-metabolism research. 5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule that stops NNMT (Nicotinamide N-methyltransferase) from working. In animal studies, blocking NNMT raised NAD+ levels and led to lower fat mass without cutting food intake or lean muscle.^[1]

Unlike NAD+ building blocks (NMN, NR), it targets the enzyme bottleneck itself instead of adding more raw material. That makes it a different and useful tool for studying NAD+ biology.

Benefits & Uses

5-Amino-1MQ is mainly used to study fat cells, NAD+ metabolism, and weight balance.^[1] Common research areas include:

• NNMT blocking and NAD+ metabolism research
• Fat cell (adipocyte) growth and biology
• SIRT1 activation and gene-regulation studies
• One-carbon metabolism research
• Obesity, metabolic syndrome, and energy-balance models
• Muscle-mass and muscle-loss (sarcopenia) models

How It Works

5-Amino-1MQ works by jamming the NNMT enzyme. Normally NNMT tags nicotinamide using a methyl donor (SAM), which uses up NAD+ building blocks and methyl groups. By blocking NNMT, it sends nicotinamide back into the NAD+ recycling pathway. This raises NAD+ inside cells, switches on SIRT1, and lowers the genes that build fat. In animal obesity models, blocking NNMT cut fat mass without changing lean mass or food intake.^[1][2]

5mg Vial Specifications

• Chemical Name: 5-Amino-1-methylquinolinium
• Molecular Formula: C₁₀H₁₀N₂ (free base)
• Molecular Weight: 174.20 Da
• Purity: ≥99% (third-party HPLC verified)
• Form: Lyophilized (freeze-dried) powder
• Vial Size: 5 mg
• Storage: −20 °C (long-term); keep away from moisture and light

Why Choose Reviv Peptides?

Reviv Peptides supplies 5-Amino-1MQ with high purity, third-party CoA paperwork, and discreet Canada-wide shipping.

Canada FAQs

How does it differ from NMN for NAD+ research?

The difference is the target. NMN adds raw material to the NAD+ pathway as a building block. 5-Amino-1MQ instead blocks the enzyme (NNMT) that drains NAD+ building blocks. Many researchers study them together to map how the NAD+ pathway is controlled.

What makes it relevant to obesity research?

It is relevant because NNMT is overactive in fat tissue during obesity. In rodent models, blocking NNMT with 5-Amino-1MQ led to lower fat mass, more energy burn, and better insulin response — all without cutting calories.^[1]

Is 5-Amino-1MQ available in Canada?

Yes. Reviv Peptides ships 5-Amino-1MQ 5 mg vials across Canada.

Reconstitution & Dosing Guide

How to Reconstitute

Add 1.0 mL of bacteriostatic water to the vial. Aim the water slowly down the inside wall of the vial — do not spray it straight onto the powder. Swirl gently until it fully dissolves; do not shake. This gives about 5.0 mg/mL. Store the mixed vial at 4 °C and use within 28 days.

Low Starting Amount

• Amount per injection: 2.5 mg — 50 units (0.50 mL) on a U-100 insulin syringe
• Frequency: Once daily, under the skin (subcutaneous)
• Cycle length: One 5 mg vial = 2 days at the starting amount

Sources: [1] Selective small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice — PubMed. [2] Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity — PubMed.