5 Amino 1 MQ – 5MG

What Is 5-Amino-1MQ? Benefits & Overview

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a selective small-molecule inhibitor of NNMT (Nicotinamide N-methyltransferase) — one of the most promising metabolic compounds available in Canada. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1-mediated fat cell metabolism, inhibits adipocyte differentiation, and improves insulin sensitivity — producing a metabolic environment that promotes lean mass preservation and fat loss simultaneously.

Unlike NAD+ precursors (NMN, NR), 5-Amino-1MQ targets the upstream enzymatic bottleneck — NNMT — rather than supplementing the pathway, making it a distinct mechanistic probe for NAD+ biology research.

5-Amino-1MQ Benefits & Uses

• NNMT inhibition and NAD+ metabolic flux research
• Adipocyte differentiation and fat cell biology
• SIRT1 activation and epigenetic regulation studies
• One-carbon metabolic pathway research
• Obesity, metabolic syndrome, and energy balance models
• Muscle mass preservation and sarcopenia models

How 5-Amino-1MQ Works

NNMT methylates nicotinamide using S-adenosylmethionine (SAM), consuming both NAD+ precursors and methyl groups. 5-Amino-1MQ competitively inhibits NNMT, redirecting nicotinamide back into the NAD+ biosynthetic salvage pathway. This raises intracellular NAD+ levels, activates SIRT1 (which deacetylates PGC-1α and other metabolic regulators), and reduces adipogenic gene expression. In preclinical obesity models, NNMT inhibition produced significant reductions in fat mass without changes to lean mass or food intake.

5-Amino-1MQ 5mg Vial Specifications

• Chemical Name: 5-Amino-1-methylquinolinium
• Molecular Formula: C₁₀H₁₀N₂ (free base)
• Molecular Weight: 174.20 Da
• Purity: ≥98% (third-party HPLC verified)
• Form: Lyophilized powder
• Vial Size: 5 mg
• Storage: −20 °C (long-term); protect from moisture and light

5-Amino-1MQ Canada FAQs

How does 5-Amino-1MQ differ from NMN for NAD+ research?

NMN directly supplements the NAD+ salvage pathway as a precursor. 5-Amino-1MQ blocks the enzyme (NNMT) that depletes NAD+ precursors — a mechanistically upstream and complementary approach. Many researchers study them together to characterise NAD+ pathway regulation.

What makes 5-Amino-1MQ relevant to obesity research?

NNMT is overexpressed in adipose tissue in obesity. Inhibiting NNMT with 5-Amino-1MQ in rodent models has produced selective reductions in fat mass, increased energy expenditure, and improved insulin sensitivity without caloric restriction.

Is 5-Amino-1MQ available in Canada?

Reconstitution & Dosing Guide

How to Reconstitute

Add 1.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not inject directly onto the powder. Gently swirl until fully dissolved; do not shake. This yields approximately 5.0 mg/mL. Store the reconstituted vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 2.5 mg — 50 units (0.50 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection
• Cycle length: One 5 mg vial = 2 days at starting dose

Start at the lowest effective dose and adjust based on individual response. Consult a qualified healthcare professional before use.