Glutathione – 1500MG

Why Buy Glutathione?

Researchers study glutathione because it is the body’s main built-in antioxidant and helps cells stay in balance. It (GSH) is a small tripeptide (γ-Glu-Cys-Gly) that protects cells from damage, supports detox pathways, and keeps the cell’s redox balance steady.^[1] Reviv Peptides offers it in Canada as a 1,500 mg lyophilized (freeze-dried) vial.

The active part of the molecule is the cysteine thiol group (–SH). This group is what lets it mop up reactive oxygen species (ROS), bind to toxins, and keep the GSH/GSSG ratio healthy inside the cell.^[1]

Benefits & Uses

Glutathione is studied across many models of oxidative stress, detox, and immune cell function. Common research uses include:

• Reactive oxygen species (ROS) scavenging and oxidative stress models^[1]
• Glutathione peroxidase (GPx) and reductase cycle research
• Liver detoxification and phase II conjugation studies^[1]
• Immune function — NK cell and T-cell activity models
• Skin melanin (pigment) inhibition and brightening research^[2]
• Neurodegeneration and mitochondrial oxidative damage models
• GSH/GSSG redox ratio assays

How It Works

Glutathione works by giving up an electron from its thiol group to neutralize ROS and reactive nitrogen species (RNS). When it does this, it turns into oxidized glutathione (GSSG), which the enzyme glutathione reductase then recycles back to the active form using NADPH.^[1] It is also the substrate for glutathione-S-transferase (GST) enzymes, which attach it to toxins so they can be flushed out in urine.^[1] In immune studies, it keeps the reducing environment that lymphocytes need to grow and signal. In pigment research, it is studied for blocking the enzyme tyrosinase and shifting melanin production from dark eumelanin toward lighter pheomelanin.^[2]

1500mg Vial Specifications

• Sequence: γ-Glu-Cys-Gly (reduced form, GSH)
• Molecular Formula: C₁₀H₁₇N₃O₆S
• Molecular Weight: 307.3 Da
• Purity: ≥99% (third-party HPLC verified)
• Form: Lyophilized (freeze-dried) powder
• Vial Size: 1,500 mg
• Storage: −20 °C (long-term); protect from air and light

Frequently Asked Questions

What is the difference between reduced and oxidized glutathione?

The difference is simple: reduced glutathione (GSH) is the active antioxidant, and oxidized glutathione (GSSG) is the used-up form. GSH has a free thiol group that does the work. GSSG is two GSH molecules joined by a disulfide bridge. The GSH:GSSG ratio is a key marker of how healthy a cell’s redox balance is.^[1] Reviv Peptides supplies the reduced (active) form.

Why is glutathione relevant to skin research?

It is relevant to skin research because it is studied for slowing melanin (pigment) production. In lab models it can block the enzyme tyrosinase and bind the copper it needs, shifting melanin toward the lighter pheomelanin type.^[2] This is why it is studied in models of dark spots and skin brightening.

Is Glutathione available in Canada?

Yes. Reviv Peptides ships these 1,500 mg vials across Canada.

Reconstitution & Dosing Guide

How to Reconstitute

Add 5.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not spray it onto the powder. Gently swirl until it fully dissolves; do not shake. This gives about 300 mg/mL. Store the mixed vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 100 mg — 33 units (0.33 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection
• Cycle length: 4–8 weeks, then 2–4 weeks off

Sources: [1] Glutathione redox balance & detoxification review — PMC. [2] Glutathione and skin lightening / tyrosinase — PMC.