NAD+ – 500MG

What Is NAD+? Benefits & Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every cell of the body and one of the most researched longevity and metabolic molecules available in Canada. Injectable NAD+ bypasses the conversion inefficiencies of oral NMN or NR supplementation, directly elevating cellular NAD+ levels to support sirtuin activation, DNA repair via PARP enzymes, mitochondrial energy production, and circadian clock regulation.

NAD+ levels decline with age — dropping approximately 50% between youth and middle age — making it a central target in research on metabolic decline, neurodegeneration, and cellular senescence. Restoring NAD+ availability in preclinical models has shown broad downstream effects on mitochondrial function, inflammation, and epigenetic regulation.

NAD+ Benefits & Uses

• Mitochondrial ATP production and oxidative phosphorylation research
• Sirtuin (SIRT1–7) activation and epigenetic deacetylation studies
• PARP-mediated DNA repair pathway research
• Ageing, cellular senescence, and longevity models
• Neurodegeneration and neuroprotection studies
• Metabolic syndrome, insulin resistance, and obesity models
• NAD+/NADH redox ratio research

How NAD+ Works

As an electron shuttle, NAD+ accepts hydride ions from glycolysis, the citric acid cycle, and beta-oxidation, delivering them to Complex I of the mitochondrial electron transport chain to drive ATP synthesis. As an enzyme substrate, NAD+ is consumed by sirtuins to deacetylate histones and transcription factors — linking cellular energy status to gene expression. PARP enzymes use NAD+ for poly-ADP-ribose synthesis during DNA strand-break repair, establishing NAD+ as a bridge between metabolism and genomic stability.

NAD+ 500mg Vial Specifications

• Full Name: β-Nicotinamide Adenine Dinucleotide (oxidised form)
• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.4 Da
• Purity: ≥98% (third-party HPLC verified)
• Form: Lyophilized powder
• Vial Size: 500 mg
• Storage: −20 °C (long-term); protect from light and moisture

Why Buy NAD+ from Reviv Peptides

Reviv Peptides supplies NAD+ at purity with third-party CoA documentation and Canada-wide discreet shipping. Our 500 mg vial size is optimised for multi-experiment research budgets.

NAD+ Canada FAQs

What is the difference between NAD+ and NMN or NR?

NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors — the body converts them to NAD+ intracellularly. For direct intracellular or cell-free assay research, NAD+ itself is used. Precursor studies investigate bioavailability and conversion pathway efficiency.

Why does NAD+ decline with age?

Age-related increases in CD38 (an NAD+ hydrolase), PARP activity (from accumulated DNA damage), and declining biosynthetic enzyme activity collectively reduce NAD+ levels. This decline is associated with impaired mitochondrial function and increased inflammatory signalling.

Is NAD+ available in Canada for research?

Reconstitution & Dosing Guide

How to Reconstitute

Add 3.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not inject directly onto the powder. Gently swirl until fully dissolved; do not shake. This yields approximately 166.7 mg/mL. Store the reconstituted vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 50 mg — 30 units (0.30 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection
• Cycle length: 8–16 weeks

Titrate slowly; some individuals begin at 25 mg.

Start at the lowest effective dose and adjust based on individual response. Consult a qualified healthcare professional before use.