NAD+ – 500MG

Why Buy NAD+?

Researchers buy NAD+ because it is one of the most studied molecules in aging and energy research. NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell. It helps cells make energy, repair DNA, and run the proteins called sirtuins.^[1] The injectable form skips the slow conversion that oral NMN or NR must go through, so it raises its levels in cells more directly.

NAD+ levels fall as we age. In human studies, they drop a lot from youth to middle age.^[2] That is why it is a key target in research on metabolism, brain aging, and worn-out cells. In lab and animal models, raising it has broad effects on energy, inflammation, and how genes are switched on and off.^[1]

Benefits & Uses

NAD+ is used to study how cells make and use energy. Researchers also use it to study DNA repair and aging.^[3] Common research areas include:

• Mitochondrial energy (ATP) and oxidative phosphorylation research
• Sirtuin (SIRT1–7) activation and gene-regulation studies
• PARP-driven DNA repair pathway research
• Aging, worn-out (senescent) cells, and longevity models
• Brain aging and nerve-protection studies
• Metabolic syndrome, insulin resistance, and obesity models
• NAD+/NADH balance (redox) research

How It Works

NAD+ works in two main ways. First, it acts like a shuttle that carries electrons from food breakdown to the cell’s power plant (the mitochondria) to make ATP energy. Second, it is used up by enzymes that control the cell. Sirtuins use it to switch genes on and off, which links a cell’s energy level to its gene activity.^[3] PARP enzymes also use it to fix broken DNA. Because these enzymes share one pool, this coenzyme ties together energy, gene control, and DNA repair.^[2]

500mg Vial Specifications

• Full Name: β-Nicotinamide Adenine Dinucleotide (oxidized form)
• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.4 Da
• Purity: ≥99% (third-party HPLC verified)
• Form: Lyophilized (freeze-dried) powder
• Vial Size: 500 mg
• Storage: −20 °C (long-term); keep away from light and moisture

Why Choose Reviv Peptides?

Reviv Peptides supplies NAD+ with high purity, third-party CoA paperwork, and discreet Canada-wide shipping. The 500 mg vial size is sized for budgets that run many experiments.

Frequently Asked Questions

What is the difference between NAD+ and NMN or NR?

The difference is that NMN and NR are building blocks, while NAD+ is the finished molecule. The body turns NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) into it inside cells. For direct cell or cell-free assay work, researchers use the molecule itself. Precursor studies look at how well the body absorbs and converts these building blocks.

Why does it decline with age?

NAD+ declines with age because cells both use up more of it and make less of it. An enzyme called CD38 breaks down more of it, PARP activity rises as DNA damage builds up, and the enzymes that make it slow down.^[2] This drop is linked to weaker energy production and more inflammation.

Is NAD+ available in Canada for research?

Yes. Reviv Peptides ships NAD+ 500 mg vials across Canada.

Reconstitution & Dosing Guide

How to Reconstitute

Add 3.0 mL of bacteriostatic water to the vial. Aim the water slowly down the inside wall of the vial — do not spray it straight onto the powder. Swirl gently until it fully dissolves; do not shake. This gives about 166.7 mg/mL. Store the mixed vial at 4 °C and use within 28 days.

Low Starting Amount

• Amount per injection: 50 mg — 30 units (0.30 mL) on a U-100 insulin syringe
• Frequency: Once daily, under the skin (subcutaneous)
• Cycle length: 8–16 weeks

Increase slowly; some protocols begin at 25 mg.

Sources: [1] Therapeutic potential of NAD-boosting molecules: the in vivo evidence — NIH / PMC. [2] The NAD+/PARP1/SIRT1 axis in aging — PubMed. [3] NAD+ and sirtuins in aging and disease — NIH / PMC.