Ipamorelin – 10MG

What Is Ipamorelin? Benefits & Overview

Ipamorelin is a selective pentapeptide growth hormone secretagogue and one of the most widely used GH-axis peptides available in Canada. By acting on the ghrelin receptor (GHSR-1a), Ipamorelin drives clean pulsatile GH release without stimulating cortisol, prolactin, or ACTH — making it one of the most selective and side-effect-friendly GH secretagogues in its class, commonly stacked with CJC-1295 for synergistic GH amplification.

Its selectivity profile is attributed to subtle structural differences from GHRP-2 and GHRP-6 that reduce activity at receptor subtypes responsible for HPA axis stimulation.

Ipamorelin Benefits & Uses

• Selective GH/IGF-1 axis stimulation without cortisol elevation
• Lean body mass and muscle accretion models
• Fat metabolism and lipolysis studies
• Sleep architecture and slow-wave sleep phase research
• GI motility and gastroparesis models (via ghrelin system)
• Recovery, repair, and anabolic biology research

How Ipamorelin Works

Ipamorelin binds GHSR-1a on anterior pituitary somatotrophs, triggering Gq protein coupling, intracellular IP₃ production, and calcium-dependent GH secretory granule exocytosis. Its selectivity for GHSR-1a over other receptor subtypes (MC2R, etc.) explains the absence of HPA axis activation. When co-administered with a GHRH analog like CJC-1295, Ipamorelin acts synergistically — CJC-1295 amplifies GH synthesis while Ipamorelin suppresses somatostatin and drives GH release — producing larger, cleaner GH pulses than either alone.

Ipamorelin 10mg Vial Specifications

• Molecular Formula: C₃₈H₄₉N₉O₅
• Molecular Weight: 711.9 Da
• Purity: ≥98% (third-party HPLC verified)
• Form: Lyophilized powder
• Vial Size: 10 mg
• Storage: −20 °C (long-term); 4 °C (short-term)
• Reconstitution: Bacteriostatic water

Ipamorelin Canada FAQs

Why is Ipamorelin considered cleaner than other GHRPs?

Ipamorelin stimulates GH release without significantly increasing cortisol, ACTH, or prolactin — side effects associated with GHRP-2 and GHRP-6. This selectivity makes it a cleaner GH secretagogue for research protocols requiring isolated GH/IGF-1 effects.

Is Ipamorelin best used with CJC-1295?

CJC-1295 + Ipamorelin is one of the most studied GHRH/GHRP combinations. CJC-1295 acts on the GHRH receptor to amplify GH production; Ipamorelin acts on GHSR-1a to drive GH release and suppress somatostatin. Together they produce synergistic GH pulses. See our dedicated CJC-1295 + Ipamorelin Blend.

Is Ipamorelin available in Canada?

Reconstitution & Dosing Guide

How to Reconstitute

Add 3.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not inject directly onto the powder. Gently swirl until fully dissolved; do not shake. This yields approximately 3.33 mg/mL. Store the reconstituted vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 100 mcg — 3 units (0.03 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection (30–60 min before bed, fasted)
• Cycle length: 8–12 weeks, then 2–4 weeks off

Start at the lowest effective dose and adjust based on individual response. Consult a qualified healthcare professional before use.