Hexarelin – 5MG

What Is Hexarelin? Benefits & Overview

Hexarelin is a synthetic hexapeptide GH secretagogue and one of the most potent GHSR-1a agonists available in Canada. Unlike Ipamorelin, Hexarelin also binds the CD36 scavenger receptor, conferring direct cardioprotective effects independent of GH release — making it uniquely positioned among GH peptides for research into cardiac ischaemia, myocardial protection, and growth hormone axis modulation simultaneously.

This dual receptor activity makes Hexarelin a particularly versatile research tool, with applications spanning GH axis pharmacology, cardiac biology, and anabolic tissue research.

Hexarelin Benefits & Uses

• Potent GH secretagogue and GHSR-1a receptor agonism research
• GH/IGF-1 axis stimulation studies
• Cardiac protection via CD36 receptor signalling
• Cardioprotection in ischaemia/reperfusion injury models
• Muscle growth and anabolic recovery research
• Fat loss and metabolic rate studies

How Hexarelin Works

At GHSR-1a, Hexarelin follows the same pathway as other GHRPs — intracellular calcium mobilisation, somatostatin suppression, and GH exocytosis — but with higher receptor affinity, resulting in larger GH pulses. Via CD36 receptors on cardiac cells, Hexarelin activates Src kinase and ERK1/2 signalling, promoting cardiomyocyte survival and reducing ischaemic cell death in preclinical cardiac injury models. This cardioprotective effect is GHSR-independent, representing a separate mechanism discovered after the peptide’s initial development.

Hexarelin 5mg Vial Specifications

• Sequence: His-D-2MeTrp-Ala-Trp-D-Phe-Lys-NH₂
• Molecular Formula: C₄₇H₅₈N₁₀O₆
• Molecular Weight: 887.0 Da
• Purity: ≥98% (third-party HPLC verified)
• Form: Lyophilized powder
• Vial Size: 5 mg
• Storage: −20 °C (long-term); 4 °C (short-term)
• Reconstitution: Bacteriostatic water

Hexarelin Canada FAQs

How does Hexarelin compare to GHRP-2?

Hexarelin typically produces larger GH pulses than GHRP-2 due to higher GHSR-1a affinity. It also binds CD36 receptors, giving it cardioprotective properties absent in GHRP-2. However, Hexarelin may produce faster receptor desensitisation at high doses in prolonged protocols.

What makes Hexarelin unique among GHRPs?

Its CD36 receptor binding is unique among GHRPs. This confers GHSR-independent cardioprotective effects, making Hexarelin valuable for combined GH axis and cardiac biology research.

Is Hexarelin available in Canada?

Reconstitution & Dosing Guide

How to Reconstitute

Add 2.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not inject directly onto the powder. Gently swirl until fully dissolved; do not shake. This yields approximately 2.5 mg/mL. Store the reconstituted vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 100 mcg — 4 units (0.04 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection
• Cycle length: 8–12 weeks

Hexarelin desensitises with extended use; cycling is recommended.

Start at the lowest effective dose and adjust based on individual response. Consult a qualified healthcare professional before use.