MOTS-c – 10MG

What Is MOTS-c? Benefits & Overview

MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of the mitochondrial genome. Available in Canada from Reviv Peptides as a 10 mg lyophilized vial, MOTS-c regulates metabolic homeostasis via AMPK activation, improves insulin sensitivity, enhances fatty acid oxidation, and has demonstrated anti-aging and exercise-mimetic effects in preclinical models — earning it a position among the most compelling longevity peptides available today.

MOTS-c circulates in human plasma and its levels decline with age, correlating with reduced metabolic flexibility and increased insulin resistance in ageing models.

MOTS-c Benefits & Uses

• AMPK activation and energy sensing pathway research
• Glucose uptake and insulin sensitivity models
• Fat oxidation and energy expenditure studies
• Mitochondrial stress response and retrograde signalling
• Exercise-mimetic and physical performance models
• Ageing and metabolic decline research
• Folate cycle and one-carbon metabolism studies

How MOTS-c Works

Under metabolic stress (glucose deprivation, oxidative stress), MOTS-c translocates from mitochondria to the nucleus where it interacts with AMPK and regulates the folate cycle — particularly the AICAR intermediate in the de novo purine synthesis pathway, which is a direct AMPK activator. AMPK activation increases GLUT4 translocation for glucose uptake, stimulates beta-oxidation, suppresses mTOR-mediated anabolism, and upregulates PGC-1α for mitochondrial biogenesis. In aged mouse models, exogenous MOTS-c restored insulin sensitivity comparable to young controls.

MOTS-c 10mg Vial Specifications

• Sequence: MRWQEMGYIFYPRKLR
• Molecular Weight: ~2,174 Da
• Purity: ≥98% (third-party HPLC verified)
• Form: Lyophilized powder
• Vial Size: 10 mg
• Storage: −20 °C (long-term); 4 °C (short-term)
• Reconstitution: Bacteriostatic water or sterile saline

MOTS-c Canada FAQs

How does MOTS-c differ from SS-31 in mitochondrial research?

SS-31 (Elamipretide) is a membrane-targeted peptide that physically stabilises the inner mitochondrial membrane and cardiolipin to improve electron transport chain efficiency. MOTS-c is a signalling peptide that translocates to the nucleus to modulate AMPK and metabolic gene expression. They work at different levels of mitochondrial biology.

Is MOTS-c considered an exercise mimetic?

In preclinical models, MOTS-c injection activates many of the same AMPK-PGC-1α pathways triggered by aerobic exercise, improving metabolic parameters without physical activity — qualifying it as an exercise-mimetic research tool for studies where physical intervention is not possible.

Is MOTS-c available in Canada?

Reconstitution & Dosing Guide

How to Reconstitute

Add 3.0 mL of bacteriostatic water to the vial. Inject the water slowly down the inside wall of the vial — do not inject directly onto the powder. Gently swirl until fully dissolved; do not shake. This yields approximately 3.33 mg/mL. Store the reconstituted vial at 4 °C and use within 28 days.

Low Starting Dose

• Dose per injection: 200 mcg — 6 units (0.06 mL) on a U-100 insulin syringe
• Frequency: Once daily, subcutaneous injection
• Cycle length: 8–12 weeks

Start at the lowest effective dose and adjust based on individual response. Consult a qualified healthcare professional before use.